Cellular Sensing of Viral DNA and Viral Evasion Mechanisms
نویسندگان
چکیده
منابع مشابه
Cellular sensing of viral DNA and viral evasion mechanisms.
Mammalian cells detect foreign DNA introduced as free DNA or as a result of microbial infection, leading to the induction of innate immune responses that block microbial replication and the activation of mechanisms that epigenetically silence the genes encoded by the foreign DNA. A number of DNA sensors localized to a variety of sites within the cell have been identified, and this review focuse...
متن کاملMINIREVIEW : Nuclear Sensing of Viral DNA versus Viral Immune Evasion
Detecting pathogenic DNA by intracellular receptors termed “sensors” is critical toward galvanizing host immune responses and eliminating microbial infections. Emerging evidence has challenged the dogma that sensing of viral DNA occurs exclusively in sub-cellular compartments normally devoid of cellular DNA.The interferon-inducible protein IFI16was shown to bind nuclear viral DNA and initiate i...
متن کاملViral Evasion of Natural Killer Cell Activation
Natural killer (NK) cells play a key role in antiviral innate defenses because of their abilities to kill infected cells and secrete regulatory cytokines. Additionally, NK cells exhibit adaptive memory-like antigen-specific responses, which represent a novel antiviral NK cell defense mechanism. Viruses have evolved various strategies to evade the recognition and destruction by NK cells through ...
متن کاملArenavirus Evasion of Host Anti-Viral Responses
The innate response to infection by an Old World arenavirus is initiated and mediated by extracellular and intracellular receptors, and effector molecules. In response, the invading virus has evolved to inhibit these responses and create the best environment possible for replication and spread. Here, we will discuss both the host's response to infection with data from human infection and lesson...
متن کاملCellular and viral control of the initiation of DNA replication.
Cell-free replication of SV40 DNA in extracts prepared from S phase cells is at least 20-fold more efficient than in extracts from G1 cells. The increased activity of S phase extracts correlates with the presence of an S phase-specific cellular factor that enhances DNA unwinding at the replication origin. This change in origin-DNA structure during the initiation of SV40 replication proceeds thr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annual Review of Microbiology
سال: 2014
ISSN: 0066-4227,1545-3251
DOI: 10.1146/annurev-micro-091313-103409